![]() Larvae of A lumbricoides reacted strongly with mAb IA6.Conclusion: Tropomyosin induces IgE responses in A lumbricoides-infected children and in patients allergic to cockroach. Strong correlation was found for IgE antibodies to tropomyosins from A lumbricoides and P americana in sera from children living in a parasite-endemic area and from patients with cockroach allergy. IgE-reactivity patterns in Asian and central European cockroach sensitized patients reveal differences in primary sensitizing allergen sources April 2022 DOI: 10.1016/j.jacig.2022.04. Cockroaches (CRs) are major indoor allergens that can pose a serious risk for respiratory allergies in sensitized subjects. The predicted structure of A lumbricoides tropomyosin was similar to that of P americana tropomyosin and showed the characteristic coiled-coil structure. Molecular modeling of P americana and A lumbricoides tropomyosins was performed by using the MODELLER program.Results: A lumbricoides tropomyosin showed 69% to 98% sequence identity to tropomyosins from other invertebrates. Presence of tropomyosin in A lumbricoides larvae at 元 stage was evaluated by immunofluorescence using mAb IA6, directed against mite tropomyosin. Santos AB, Chapman MD, Aalberse RC, et al. ![]() Levels of IgE to tropomyosins from A lumbricoides and P americana were determined by chimeric ELISA in sera from 119 children living in a parasite-endemic area and 112 patients with cockroach allergy from the allergy clinics. 10. Background: Evidence indicates that infection with Ascaris lumbricoides may promote development of allergy and asthma.Objective: To study the role of tropomyosin, a pan-allergen in invertebrates, in IgE responses to A lumbricoides.Methods: Recombinant A lumbricoides and Periplaneta americana tropomyosins were expressed in Pichia pastoris.
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